I don't have Virgin so can't confirm this but if you are trying to use Bluetooth you can't as the box only pairs to one remote and will be paired to the original one (no idea if it's possible to unpair the original and pair the X1s). However you should be able to use IR, VirginMedia is listed in IR but may not be the 360. Try adding “Ziggo Mediabox Next” (apparently the 360 is the same).